We are a team of creative, ambitious and friendly researchers who investigate membrane transport processes in pathogenic bacteria and develop innovative protein engineering tools. We combine the disciplines of structural biology, binder generation, protein biochemistry and microbiology to uncover molecular details of how membrane transport proteins expel antibiotics, shuttle siderophores and export lipids. Sybodies and NestLink enable us to target membrane transporters in the cellular context to develop rapid diagnostics, novel antibiotics and tailor-made research tools.
Just amazing🤩 Structures of XKR scramblases, involved in apoptotic singling from the Dutzler lab. Only 43kDa big🤯 Huge compliment to my former lab, in particular to the amazing work done by @Monique86321774, I remember how @CarolinaAlvadia started it. https://t.co/OQZpyBHtZj
Relevant to millions of schizophrenia patients: view on the inhibited SLC transporter GlyT1 published in @nature. Enabled by @Roche, @embl, @UZH_en, @AarhusUni_int and #Sybody technology by @LinksterTx.
#Biotechnology #precisionmedicine #antibodies
Warfare against pathogenic bacteria has paved a long way! Published today @nature we resolve how the natural antibiotic Darobactin kills Gram negative bacteria by mimicking a ß-strand targeting the surface exposed BAM complex.