We are a team of creative, ambitious and friendly researchers who investigate membrane transport processes in pathogenic bacteria and develop innovative protein engineering tools. We combine the disciplines of structural biology, binder generation, protein biochemistry and microbiology to uncover molecular details of how membrane transport proteins expel antibiotics, shuttle siderophores and export lipids. Sybodies and NestLink enable us to target membrane transporters in the cellular context to develop rapid diagnostics, novel antibiotics and tailor-made research tools.
Our paper with @PoulNissen R.J.P. Dawson T.R. Schneider @seegerlab P. Stohler G. Bourenkov @iwan_zimmermann W. Guba E. Pinard M. Siegrist @staev01 is out @nature https://t.co/TAaGAWJVgA
@dandrite @MolBiolAU @EMBLHamburg @embl @Roche & LinksterTX @novonordiskfond @lundbeckfonden
An ABC transporter wearing a crooked bow tie! 🤵Beautiful work by Jochen Zimmer's lab @MedicineUVA on O antigen transport required for LPS production in gram-negative bacteria! A dimeric carbohydrate binding domain binds to one NBD with striking asymmetry:
Don't miss the talk of Prof. Dr. Kaspar Locher at Frontiers in Medicinal Chemistry 2021:
Structural studies of substrate and inhibitor binding to multidrug transporters by cryo-electron microscopy.
Mar 10, 10:45 a.m. UTC+1
@lab_locher #CryoEM https://t.co/FNZvti7fPR