We are a team of creative, ambitious and friendly researchers who investigate membrane transport processes in pathogenic bacteria and develop innovative protein engineering tools. We combine the disciplines of structural biology, binder generation, protein biochemistry and microbiology to uncover molecular details of how membrane transport proteins expel antibiotics, shuttle siderophores and export lipids. Sybodies and NestLink enable us to target membrane transporters in the cellular context to develop rapid diagnostics, novel antibiotics and tailor-made research tools.
Warfare against pathogenic bacteria has paved a long way! Published today @nature we resolve how the natural antibiotic Darobactin kills Gram negative bacteria by mimicking a ß-strand targeting the surface exposed BAM complex.
Very happy that our review on molecular mechanisms for bacterial potassium homeostasis, written together with Randy Stockbridge's lab, is online. We hope that particularly microbiologists studying potassium transport find it helpful.
And finally online - Part 2 of the fantastic ABC transporter Special Edition! Don't miss it and big thanks to all the fantastic contributors!
Beautiful cover this time inspired by @seegerlab, Oded Lewinson and Cedric Orelle!!
leadXpro is happy to report the structure of LptDE - solved by cryo-EM at high resolution - which provides structural basis for the discovery of novel antibiotics targeting lipopolysaccharide (LPS) transport on the bacteria outer membrane. https://t.co/IkUonqDWCG https://t.co/uEm8T4lqbB