We are a team of creative, ambitious and friendly researchers who investigate membrane transport processes in pathogenic bacteria and develop innovative protein engineering tools. We combine the disciplines of structural biology, binder generation, protein biochemistry and microbiology to uncover molecular details of how membrane transport proteins expel antibiotics, shuttle siderophores and export lipids. Sybodies and NestLink enable us to target membrane transporters in the cellular context to develop rapid diagnostics, novel antibiotics and tailor-made research tools.
Closing the scientific program of the day with the Technologies session with four exciting presentations from @mattia_zampieri @lab_maier @JWVeening lab and @seegerlab. What a day at the 2022 SSM meeting ! @SwissMicrobe https://t.co/JFy4RCMcQ7
Take a look at our latest structures - Ferroportin in complex with a first clinical-stage oral inhibitor vamifeport from @CSLVifor competing with its regulatory peptide hormone hepcidin. Exciting results within the iron-project funded by @NCCR_TransCure.
Check out our newest review on #cryoEM (of membrane proteins) at 200 keV. Take home message: don’t treat your 200keV TEM only as a screening machine 😉. Fantastic work by @chancie_t and @rheinbergerj 👇🏼 https://t.co/gdSAZJf3LV https://t.co/aSmnkCPOQe