Our mission
We are a team of creative, ambitious and friendly researchers who investigate membrane transport processes in pathogenic bacteria and develop innovative protein engineering tools. We combine the disciplines of structural biology, binder generation, protein biochemistry and microbiology to uncover molecular details of how membrane transport proteins expel antibiotics, shuttle siderophores and export lipids. Sybodies and NestLink enable us to target membrane transporters in the cellular context to develop rapid diagnostics, novel antibiotics and tailor-made research tools.
Together with @BarlandNatalie, here we show how to use Solid-Supported-Membrane (SSM) electrophysiology to select transporters-targeted inhibitory nanobodies
https://t.co/a9vtLwwAP2
Just amazing🤩 Structures of XKR scramblases, involved in apoptotic singling from the Dutzler lab. Only 43kDa big🤯 Huge compliment to my former lab, in particular to the amazing work done by @Monique86321774, I remember how @CarolinaAlvadia started it. https://t.co/OQZpyBHtZj
Nice structural work on a new protein family from the Dutzler lab! 👏🏻 Pushing the size limit of membrane protein cryoEM! 👀 Great use of sybodies ( @seegerlab) and cryoSPARC ( @structurabio). https://t.co/z0baWHeBiG https://t.co/fWCZff12xH
Congratulations to Christian Heinis for winning an @ERC_Research #AdvancedGrant!
https://t.co/JxchbAk3EP
@EPFL_CHEM_Tweet https://t.co/qYs4pzTFY9
Relevant to millions of schizophrenia patients: view on the inhibited SLC transporter GlyT1 published in @nature. Enabled by @Roche, @embl, @UZH_en, @AarhusUni_int and #Sybody technology by @LinksterTx.
#Biotechnology #precisionmedicine #antibodies
https://t.co/ZVf86vpNrk https://t.co/TQ4bnB1R2C
Warfare against pathogenic bacteria has paved a long way! Published today @nature we resolve how the natural antibiotic Darobactin kills Gram negative bacteria by mimicking a ß-strand targeting the surface exposed BAM complex.
@biozentrum @NCCR_AntiResist
https://t.co/k6Qv8idgOr https://t.co/Jfew2hK7oY
