PUBLICATIONS
MycoTransport
2020 Nature, 580(7803): p. 413-417
The ABC exporter IrtAB imports and reduces mycobacterial siderophores
Authors: F.M. Arnold, M.S. Weber, I. Gonda, M.J. Gallenito, S. Adenau, P. Egloff, I. Zimmermann, C.A.J. Hutter, L.M. Hürlimann, E.E. Peters, J. Piel, G. Meloni, O. Medalia, and M.A. Seeger*
2019 Mol Microbiol
Increased drug permeability of a stiffened mycobacterial outer membrane in cells lacking MFS transporter Rv1410 and lipoprotein LprG
Authors: M. Hohl#, S. Remm#, H.A. Eskandarian, M. Dal Molin, F.M. Arnold, L.M. Hürlimann, A. Krügel, G.E. Fantner, P. Sander, and M.A. Seeger*
DrugEfflux
2012 Nat Struct Mol Biol, 19(4): p. 395-402.
Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation
Authors: M. Hohl, C. Briand, M.G. Grütter*, and M.A. Seeger*
Sybodies
2022 Nature Communications, 13 (1):1826
Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation
Authors: M. Botte, D. Ni, S. Schenck, I. Zimmermann, M. Chami, N. Bocquet, P. Egloff, D. Bucher, M. Trabuco, R.K.Y. Cheng, J.D. Brunner, M.A. Seeger, H. Stahlberg, M. Hennig
2022 EMBO reports, 23(4):e54199
Biparatopic sybodies neutralize SARS-CoV-2 variants of concern and mitigate drug resistance
Authors: J.D. Walter#, M. Scherer#, C.A.J. Hutter#, A.A. Garaeva#, I. Zimmermann, M. Wyss, J. Rheinberger, Y. Ruedin, J.C. Earp, P. Egloff, M. Sorgenfrei, L.M. Hürlimann, I. Gonda, G. Meier, S. Remm, S. Thavarasah, G. van Geest, R. Bruggmann, G. Zimmer, D.J. Slotboom, C. Paulino*, P. Plattet*, M.A. Seeger*
2021 Nature Communications, 12(1):4635
A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection
Authors: T. Li, H. Cai, H. Yao, B. Zhou, N. Zhang, M.F. van Vlissingen, T. Kuiken, W. Han, C.H. GeurtsvanKessel, Y. Gong, Y. Zhao, Q. Shen, W. Qin, X. Tian, C. Peng, Y. Lai, Y. Wang, C.A.J. Hutter, S. Kuo, J. Bao, C. Liu, Y. Wang, A.S. Richard, H. Raoul, J. Lan, M.A. Seeger, Y. Cong, B. Rockx, G. Wong, Y. Bi, D. Lavillette, D. Li
2020 Nature communications, 11(1):5588
Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2
Authors: T.F. Custódio, H. Das, D.J. Sheward, L. Hanke, S. Pazicky, J. Pieprzyk, M. Sorgenfrei, M.A. Schroer, A.Y. Gruzinov, C.M. Jeffries, M.A. Graewert, D.I. Svergun, N. Dobrev, K. Remans, M.A. Seeger, G.M. McInerney, B. Murrell, B M. Hällberg, C. Löw
2020 Nat Protoc, 15(5): p. 1707-1741
Generation of synthetic nanobodies against delicate proteins
Authors: I. Zimmermann, P. Egloff, C.A.J. Hutter, B.T. Kuhn, P. Bräuer, S. Newstead, R.J.P. Dawson, E.R. Geertsma*, and M.A. Seeger*
2019 Science, 363(6431): p. 1103-1107
Structural basis for pH-dependent retrieval of ER proteins from the Golgi by the KDEL receptor
Authors: P. Bräuer, J.L. Parker, A. Gerondopoulos, I. Zimmermann, M.A. Seeger, F.A. Barr, and S. Newstead
2018 Elife, 7.
Synthetic single domain antibodies for the conformational trapping of membrane proteins
Authors: I. Zimmermann#, P. Egloff#, C.A. Hutter, F.M. Arnold, P. Stohler, N. Bocquet, M.N. Hug, S. Huber, M. Siegrist, L. Hetemann, J. Gera, S. Gmur, P. Spies, D. Gygax, E.R. Geertsma*, R.J. Dawson*, and M.A. Seeger*
NestLink
2020 Nature, 580(7803): p. 413-417
The ABC exporter IrtAB imports and reduces mycobacterial siderophores
Authors: F.M. Arnold, M.S. Weber, I. Gonda, M.J. Gallenito, S. Adenau, P. Egloff, I. Zimmermann, C.A.J. Hutter, L.M. Hürlimann, E.E. Peters, J. Piel, G. Meloni, O. Medalia, and M.A. Seeger*